{"id":10585,"date":"2021-04-23T11:34:35","date_gmt":"2021-04-23T09:34:35","guid":{"rendered":"https:\/\/natureight.com\/?p=10585"},"modified":"2021-04-23T11:35:47","modified_gmt":"2021-04-23T09:35:47","slug":"comment-les-cannabinoides-influent-sur-les-tremblements-pathologiques","status":"publish","type":"post","link":"https:\/\/natureight.com\/fr\/effets-et-etudes-du-cbd\/comment-les-cannabinoides-influent-sur-les-tremblements-pathologiques\/","title":{"rendered":"Comment les cannabino\u00efdes influent sur les tremblements pathologiques ?"},"content":{"rendered":"

R\u00e9cemment publi\u00e9e en mars 2021 dans la revue Nature Neuroscience, l\u2019\u00e9tude intitul\u00e9e \u00ab\u00a0Spinal astroglial cannabinoid receptors control pathological tremor\u00a0\u00bb<\/a> explique comment les cannabino\u00efdes influent sur les tremblements pathologiques.<\/p>\n

Men\u00e9es par le D\u00e9partement des Neurosciences de la Facult\u00e9 des Sciences M\u00e9dicales et de la Sant\u00e9 de l\u2019Universit\u00e9 de Copenhague, ces recherches repr\u00e9sentent une belle avanc\u00e9e pour les patients atteints de mouvements incontr\u00f4lables de leur corps.<\/p>\n

L\u2019action des cannabino\u00efdes sur les astrocytes de la moelle \u00e9pini\u00e8re<\/h2>\n

Relais entre le cerveau et le corps, la moelle \u00e9pini\u00e8re assure la transmission des messages nerveux. Elle est constitu\u00e9e de neurones et de cellules gliales comme les astrocytes, qui sont des cellules en forme d\u2019\u00e9toile. Intimement li\u00e9es aux neurones, les astrocytes jouent un r\u00f4le essentiel dans la transmission des messages nerveux en facilitant la transmission synaptique notamment par la lib\u00e9ration de purines (neurotransmetteurs).<\/p>\n

Dans l\u2019\u00e9tude pr\u00e9cit\u00e9e, la diminution des tremblements pathologiques gr\u00e2ce au cannabis a \u00e9t\u00e9 constat\u00e9 sur des souris. Les chercheurs ont r\u00e9ussi \u00e0 mettre en \u00e9vidence l\u2019effet inhibiteur du cannabis sur les secousses involontaires et incontr\u00f4lables du corps\u00a0: les cannabino\u00efdes agissent sur la communication neuronale en se fixant sur les r\u00e9cepteurs des astrocytes. Ce m\u00e9canisme induit une modification du message \u00e0 transmettre par les neurones et, par cons\u00e9quent, une modification de la r\u00e9ponse musculaire associ\u00e9e.<\/p>\n

Rien qu\u2019aux \u00c9tats-Unis ces troubles, issus de maladies neurod\u00e9g\u00e9n\u00e9ratives ou de traumatismes, concernent plus de 200 000 personnes. Les cannabino\u00efdes repr\u00e9sentent donc un espoir pour toutes ces personnes souffrant de tremblements involontaires de la t\u00eate ou des membres.<\/p>\n

Les perspectives de gu\u00e9rison des tremblements pathologiques par les cannabino\u00efdes<\/h2>\n

Selon Jean-Fran\u00e7ois Perrier, PhD, l\u2019\u00e9tude ne s\u2019est int\u00e9ress\u00e9e jusqu\u2019\u00e0 pr\u00e9sent qu\u2019au traitement des tremblements pathologiques incontr\u00f4lables, qui peuvent consid\u00e9rablement impacter la qualit\u00e9 de vie des patients. Il en vient \u00e0 supposer que les mol\u00e9cules de cannabino\u00efdes pourraient \u00eatre efficaces sur d\u2019autres maladies ou d\u2019autres facteurs \u00e0 l\u2019origine de ces troubles telles que la scl\u00e9rose<\/a> ou des l\u00e9sions de la moelle \u00e9pini\u00e8re.<\/p>\n

Alors que les pr\u00e9c\u00e9dentes \u00e9tudes \u00e9taient plut\u00f4t centr\u00e9es sur les neurones, celle-ci a permis de mettre en \u00e9vidence l\u2019action des cannabino\u00efdes sur les astrocytes.<\/p>\n

\u00ab\u00a0Nous avons d\u00e9couvert qu\u2019une injection du cannabino\u00efde WIN55,212-2 dans la moelle \u00e9pini\u00e8re active les astrocytes de la moelle \u00e9pini\u00e8re et les incite \u00e0 lib\u00e9rer la substance ad\u00e9nosine, qui r\u00e9duit ensuite l\u2019activit\u00e9 nerveuse et donc le tremblement ind\u00e9sirable.\u00a0\u00bb affirme Jean-Fran\u00e7ois Perrier. Un traitement plus cibl\u00e9 avec moins d\u2019effets secondaires pourraient voir le jour suite \u00e0 cette d\u00e9couverte.<\/p>\n

Eva Carlsen, une autre scientifique ayant collabor\u00e9 \u00e0 l\u2019\u00e9tude, imagine elle aussi la mise au point d\u2019un traitement aux cannabino\u00efdes ciblant tr\u00e8s pr\u00e9cis\u00e9ment les astrocytes de la moelle \u00e9pini\u00e8re. Ce type de traitement localis\u00e9, plus efficace, permettrait de ne pas affecter les neurones du cerveau et de ne pas impacter la m\u00e9moire ou les capacit\u00e9s cognitives des patients. Ce qui r\u00e8glerait le probl\u00e8me des effets secondaires du cannabis m\u00e9dical traditionnel.<\/p>\n

Le contr\u00f4le des tremblements pathologiques par les r\u00e9cepteurs cannabino\u00efdes des astrocytes<\/h2>\n

Qu\u2019il soit volontaire ou non, tout mouvement est d\u00e9clench\u00e9 par l\u2019activation des neurones moteurs de la moelle \u00e9pini\u00e8re, appel\u00e9s motoneurones. Les mouvements involontaires et les tremblements pathologiques peuvent s\u2019expliquer par l\u2019envoi de signaux contradictoires de ces neurones moteurs.<\/p>\n

La compr\u00e9hension des m\u00e9canismes des motoneurones et l\u2019\u00e9tude des effets des cannabino\u00efdes sur ces cellules a permis de r\u00e9v\u00e9ler l\u2019impact positif du cannabis sur les tremblements pathologiques.<\/p>\n

Une fois de plus, ces recherches pointent du doigt le pouvoir du cannabis m\u00e9dical, et plus particuli\u00e8rement des cannabino\u00efdes, dans le traitement de pathologies sp\u00e9cifiques et difficiles \u00e0 gu\u00e9rir.<\/p>\n

La mise au point d\u2019un traitement cibl\u00e9 sur les cellules de la moelle \u00e9pini\u00e8re serait un \u00e9norme soulagement pour toute personne affect\u00e9e par des tremblements pathologiques.<\/p>\n","protected":false},"excerpt":{"rendered":"

R\u00e9cemment publi\u00e9e en mars 2021 dans la revue Nature Neuroscience, l\u2019\u00e9tude intitul\u00e9e \u00ab\u00a0Spinal astroglial cannabinoid receptors control pathological tremor\u00a0\u00bb explique comment les cannabino\u00efdes influent sur les tremblements pathologiques. Men\u00e9es par le D\u00e9partement des Neurosciences de la Facult\u00e9 des Sciences M\u00e9dicales et de la Sant\u00e9 de l\u2019Universit\u00e9 de Copenhague, ces recherches repr\u00e9sentent une belle avanc\u00e9e pour … <\/p>\n

Lire la suite<\/a><\/p>\n","protected":false},"author":1099,"featured_media":10586,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"generate_page_header":"","mc4wp_mailchimp_campaign":[],"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[214],"tags":[],"class_list":["post-10585","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-effets-et-etudes-du-cbd","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-50"],"yoast_head":"\nComment les cannabino\u00efdes influent sur les tremblements pathologiques ?<\/title>\n<meta name=\"description\" content=\"L'utilisation cibl\u00e9e des cannabino\u00efdes permettrait de traiter les tremblements pathologiques. 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