Cannabidiol or CBD is one of the many cannabinoids found inside the plant Cannabis sativa L. Unlike THC, which causes several side effects, CBD has no psychoactive effect, meaning that it does not cause any intoxicating feeling, dizziness or euphoria.
HEMP AND CANNABIS: THE DIFFERENCE
Although they belong to the same family of plants, hemp plants particularly derive from varieties of Cannabis Sativa L. which have been deliberately cross-pollinated and grown for industrial and agricultural purposes. These plants only contain a very slight quantity of THC (less than 0.2%) and most importantly, they cause no psychoactive effects, thereby complying with European laws.
Hemp plants used by Natureight are grown from seeds that are certified by the French cooperative C.C.P.S.C.
Cannabinoids are chemical compounds mainly produced by the cannabis plant. Until today, over 144 cannabinoids have been identified. THC is the only psychoactive one. Taking into account all the other 143 non-psychoactive cannabinoids, CBD is the most studied.
According to Hampson AJ, Grimaldi M, Lolic M, Wink D, Rosenthal R & Axelrod J (2000), who published Neuroprotective antioxidants from marijuana:
Cannabinoids are powerful antioxidants and neuroprotectants
- ANTIOXIDANTS act as free radical scavengers. Free radicals are responsible for cell aging, among other things. Antioxidants have many positive effects, such as reducing cholesterol levels, preventing cardiovascular diseases and cancers, or even protecting the eyes.
- NEUROPROTECTORS promote healthy functioning of the central nervous system. They prevent and slow disease progression, as well as secondary injuries, simply by stopping or at least slowing the loss of neurons.
THE ENDOCANNABINOID SYSTEM
The Endocannabinoid System consists of a group of cell receptors and molecules found inside our bodies. It is actually the system which facilitates homeostasis, a regulatory process that keeps the body balanced and functioning normally. Therefore, the Endocannabinoid System has an influence on all essential body functions, such as hunger, digestion, pain, energy, sleep, motor and reproductive functions, pleasure, temperature regulation, etc.
The cell receptors that form part of the system, which are called cannabinoid receptors, were identified during the 1990s through a study on how cannabis acts on the brain. They take their name from the word “cannabis”, along with the prefix “endo”, meaning they are produced by the body.
More precisely, they are proteins that receive chemical signals from the outside of a cell. When one of these signals binds to a receptor, a cellular response follows.
Cannabinoid receptors respond to three types of binders:
- Endocannabinoids produced by mamillary bodies (a part of the brain located near the hypothalamus),
- Phyto-cannabinoids mainly produced by the cannabis plant,
- Synthetic cannabinoids.
A modification within the Endocannabinoid System is known as a “endocannabinoid deficiency syndrome”. Your organism is no-longer functioning normally because it does not produce enough endocannabinoids or enough receptors in natural way. As a result, some functions are not regulated properly and the body becomes unbalanced, allowing diseases to arise. Hence, It is vital to correct this disturbance. CBD is a naturally-occurring phyto-cannabinoid that is present in the hemp plant, making it a good option in your quest for well-being.
FULL SPECTRUM EXTRACT : THE ENTOURAGE EFFECT
In 1964, the Israeli professor Raphael Mechoulam isolated THC and CBD. His aim was to develop a drug from just one of these two molecules. However, in 1999 he discovered that cannabinoids work best when combined with other components of the plant (terpenes, amino acids, proteins, sugars, enzymes, fatty acids, esters and flavonoids, to name but a few). In fact, the other active ingredients within the plant improve the therapeutic effects of CBD; a process called the Entourage Effect. Cannabinoids and other ingredients work in synergy, having an effect on the body through a similar mechanism.
Full-spectrum CBD extract (that comes from a plant extract) is therefore incomparably more effective than isolated CBD (crystal CBD).
You can find one of the studies that has been carried out on the subject by the Lautenberg Center for Immunology and Cancer Research in Jerusalem by clicking here
THE BENEFITS OF CBD
Below is a non-exhaustive list of conditions and disorders that are known to benefit from medicinal or medical treatment with cannabinoids. The list was created by the International Cannabinoid Research Society:
- Addiction and withdrawal
- Anxiety / stress disorders
- Brain injury
- Some Cancers
- Cerebral palsy
- Chronic migraines
- Crohn’s disease
- Hepatitis C
- Irritable bowel syndrome
- Multiple sclerosis
- Muscular dystrophy
- Pain / chronic pain
- Parkinson’s disease
- Seizure disorders
- Sleep disorders
- Spinal cord injury
During its growth, hemp produces Cannabidiolic Acid (CBDA) but not directly CBD. When heated, CBDA loses its carbon atom and becomes CBD: it is the process of decarboxylation. Therefore, the CBDA is a cannabinoid precursor of CBD.
Like CBD, CBDA does not have a psychoactive effect and plays its role in the Entourage Effect. It was previously considered as an inactive molecule, but recent research has shown that this molecule has much to offer:
- Antibacterial: A study completed in 2000 notes that more CBD-A in a plant will lead to greater antimicrobial potency within the CBD that results after decarboxylation.
- Anti-Nausea: A 2013 study published in the British Journal of Pharmacology showed that CBD-A could be used as an alternative to THC when it comes to preventing nausea and vomiting, and it doesn’t offer the psychoactive properties of THC. It has also been shown to have significant benefits in helping with anticipatory nausea experienced by chemotherapy patients.
- Cancer: CBD-A is thought to be one of many cannabinoids that can help to control the growth of tumors in cancer patients. A 2012 study published in Toxicology Letters found that CBDA could work to inhibit the migration of breast cancer cells.